Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …

Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal
cell death and the release of factors such as damage-associated molecular patterns …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held
beliefs, we now know that resident macrophages in many organs are seeded during …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging
biomarker of reference to measure increased neuroinflammation. Generally assumed to …

Microglia, as cellular mediators of neuroinflammation, are implicated in the pathogenesis of
a wide range of neurodegenerative diseases. Positron emission tomography (PET) imaging …

Stroke remains the leading cause of long-term disability worldwide with significant long-term
sequelae. However, there is no highly effective treatment to enhance post-stroke recovery …