Structural specialisations enable von Willebrand factor (VWF) to assemble during
biosynthesis into helical tubules in Weibel‐Palade bodies (WPB). Specialisations include a …

The process of hemostatic plug formation at sites of vascular injury crucially relies on the
large multimeric plasma glycoprotein von Willebrand factor (VWF) and its ability to recruit …

Von Willebrand factor (VWF) is secreted as ultralarge multimers that are cleaved in the A2
domain by the metalloprotease ADAMTS13 to give smaller multimers. Cleaved VWF is …

Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases
such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly …

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet
adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von …

Because of its protein-denaturing ability, urea has played a pivotal role in the experimental
and conceptual understanding of protein folding and unfolding. The measure of urea's ability …

Protein A (Spa) is a surface‐associated protein of Staphylococcus aureus best known for its
ability to bind to the Fc region of IgG. Spa also binds strongly to the Fab region of the …

Macromolecules and cells exposed to blood flow in the circulatory tree experience
hydrodynamic forces that affect their structure and function. After introducing the general …

A disintegrin and metalloprotease with a thrombospondin type 1 motifs 13 (ADAMTS-13)
regulates hemostasis by cleaving the folded A2 domain of von Willebrand factor (VWF). The …

Background: von Willebrand factor (VWF) does not interact with circulating platelets unless it
is induced to expose the binding site for platelet glycoprotein (GP) Ibα in the A1 domain by …