Microtubule “plus-end-tracking proteins”: the end is just the beginning

SC Schuyler, D Pellman - Cell, 2001 - cell.com
Microtubule “Plus-End-Tracking Proteins”: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research Submit …

Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives

E Nogales, HW Wang - Current opinion in structural biology, 2006 - Elsevier
The αβ-tubulin dimer assembles into microtubules, essential polymers in all eukaryotic cells.
Microtubules are highly dynamic, a property that derives from tubulin's GTPase activity. Both …

Refined structure of αβ-tubulin at 3.5 Å resolution

J Löwe, H Li, KH Downing, E Nogales - Journal of molecular biology, 2001 - Elsevier
We present a refined model of the αβ-tubulin dimer to 3.5 Å resolution. An improved
experimental density for the zinc-induced tubulin sheets was obtained by adding 114 …

[HTML][HTML] EBs recognize a nucleotide-dependent structural cap at growing microtubule ends

SP Maurer, FJ Fourniol, G Bohner, CA Moores… - Cell, 2012 - cell.com
Growing microtubule ends serve as transient binding platforms for essential proteins that
regulate microtubule dynamics and their interactions with cellular substructures. End …

Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans

D Xu, B Jiang, T Ketela, S Lemieux, K Veillette… - PLoS …, 2007 - journals.plos.org
Candida albicans is a prevalent fungal pathogen amongst the immunocompromised
population, causing both superficial and life-threatening infections. Since C. albicans is …

The SPIRAL genes are required for directional control of cell elongation in Arabidopsis thaliana

I Furutani, Y Watanabe, R Prieto, M Masukawa… - …, 2000 - journals.biologists.com
Cells at the elongation zone expand longitudinally to form the straight central axis of plant
stems, hypocotyls and roots, and transverse cortical microtubule arrays are generally …

CetZ tubulin-like proteins control archaeal cell shape

IG Duggin, CHS Aylett, JC Walsh, KA Michie, Q Wang… - Nature, 2015 - nature.com
Tubulin is a major component of the eukaryotic cytoskeleton, controlling cell shape, structure
and dynamics, whereas its bacterial homologue FtsZ establishes the cytokinetic ring that …

Microtubule assembly dynamics: an attractive target for anticancer drugs

P Singh, K Rathinasamy, R Mohan, D Panda - IUBMB life, 2008 - Wiley Online Library
Microtubules, composed of αβ tubulin dimers, are dynamic polymers of eukaryotic cells.
They play important roles in various cellular functions including mitosis. Microtubules exhibit …

Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an α-tubulin mutation

LA Martello, P Verdier-Pinard, HJ Shen, L He, K Torres… - Cancer research, 2003 - AACR
The A549 Taxol-resistant cell lines, A549-T12 and A549-T24, were isolated in our
laboratory, and aredependent on Taxol for normal growth. The microtubules inthese cells …

Evolution of the cytoskeleton

HP Erickson - Bioessays, 2007 - Wiley Online Library
The eukaryotic cytoskeleton appears to have evolved from ancestral precursors related to
prokaryotic FtsZ and MreB. FtsZ and MreB show 40–50% sequence identity across different …