Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin
family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative
disease. Although the pathogenesis remains unresolved, oxidative stress is known to play a …

The process of neuronal degeneration in motor neurone disease is complex. Several
genetic alterations may be involved in motor neurone injury in familial amyotrophic lateral …

Objective Amyotrophic lateral sclerosis (ALS) is a devastating, and currently incurable,
neuromuscular disease in which oxidative stress and mitochondrial impairment are …

Motor unit (MU) enlargement by sprouting is an important compensatory mechanism for loss
of functional MUs during normal aging and neuromuscular disease. Perisynaptic Schwann …

A large number of physiologically functional foods are comprised of plant polyphenols. Their
antioxidative activities have been intensively studied for a long period and proposed to be …

Familial amyotrophic lateral sclerosis (FALS) is caused, in 20% of cases, by mutations in the
Cu/Zn superoxide dismutase gene (SOD1). Although motor neuron injury occurs through a …