For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on mapping integration sites in libraries of random transposon mutants to …

Mycobacterium tuberculosis can survive within its host for extended periods of time without
any clinical symptoms of disease and reactivate when the immune system is weakened. A …

Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …

Abstract Background Dormant Mycobacterium tuberculosis bacilli are believed to play an
important role in latent tuberculosis infection. Previously, we have demonstrated that …

One key to the success of Mycobacterium tuberculosis as a pathogen is its ability to reside in
the hostile environment of the human macrophage. Bacteria adapt to stress through a variety …

Bacterial small regulatory RNAs (sRNAs) are the most abundant class of post-transcriptional
regulators and have been well studied in Gram-negative bacteria. Little is known about the …

Infectious diseases caused by bacterial pathogens still constitute one of the major human
health threats (1). Within the host body, pathogenic bacteria face a wide variety of hostile …

Post-transcriptional regulation, by small RNAs (sRNAs) as well as the global Carbon
Storage Regulator A (CsrA) protein, play critical roles in bacterial metabolic control and …

The capacity of Mycobacterium tuberculosis (Mtb) to sense, respond and adapt to a variable
and hostile environment within the host makes it one of the most successful human …

Since the turn of the millenium, RNA-based control of gene expression has added an extra
dimension to the central dogma of molecular biology. Still, the roles of Mycobacterium …