The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

The kidneys' integrative responses to heat stress aid thermoregulation, cardiovascular
control, and water and electrolyte regulation. Recent evidence suggests the kidneys are at …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

The assignment of cell type names to individual cell clusters in single-cell RNA-sequencing
(RNA-seq; including single-nucleus RNA-seq) studies is a critical bioinformatic step …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

The extracellular domain of the (pro) renin receptor (PRR) is cleaved to produce a soluble
(pro) renin receptor (sPRR) that is detected in biological fluid and elevated under certain …

Cardiovascular disease is a pathology that exhibits well-researched biological sex
differences, making it possible for physicians to tailor preventative and therapeutic …

A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying
mechanism largely remains unknown. The major goal of the present study was to test the …

Emerging evidence has demonstrated that (pro) renin receptor (PRR)-mediated activation of
intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ …

Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase
activities. Among prostaglandins (PGs), prostacyclin (PGI 2) and PGE 2 are strongly involved …