Hepatotoxicity of food-borne mycotoxins: Molecular mechanism, anti-hepatotoxic medicines and target prediction

H Ruan, Q Lu, J Wu, J Qin, M Sui, X Sun… - Critical Reviews in …, 2022 - Taylor & Francis
Mycotoxins are metabolites produced by fungi. The widespread contamination of food and
feed by mycotoxins is a global food safety problem and a serious threat to people's health …

Dietary aflatoxin B1 caused the growth inhibition, and activated oxidative stress and endoplasmic reticulum stress pathway, inducing apoptosis and inflammation in …

M Li, Y Kong, W Guo, X Wu, J Zhang, Y Lai… - Science of The Total …, 2022 - Elsevier
The purpose of this study was to investigate the effects of dietary aflatoxin B 1 (AFB 1) on
growth performance and AFB 1 biotransformation, and hepatic oxidative stress, endoplasmic …

Degradation of aflatoxin B1 by a recombinant laccase from Trametes sp. C30 expressed in Saccharomyces cerevisiae: A mechanism assessment study in vitro and in …

Y Liu, H Mao, KW Yohannes, Z Wan, Y Cao… - Food Research …, 2021 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) is the most harmful mycotoxin and presents risks to human
health. Utilization of enzyme to degrade AFB1 is a promising strategy to overcome this …

Encapsulation of cinnamon essential oil in whey protein enhances the protective effect against single or combined sub-chronic toxicity of fumonisin B 1 and/or …

MA Abdel-Wahhab, AA El-Nekeety, NS Hassan… - … Science and Pollution …, 2018 - Springer
Abstract Fumonisin B 1 (FB 1) and aflatoxin B 1 (AFB 1) are fungal metabolites that
frequently co-occur in foodstuffs and are responsible for mycotoxicosis and several primary …

[HTML][HTML] Free radicals and actinobacteria as a misexplored goldmine of antioxidant compounds

THB OLIVEIRA, NB GUSMÃO, LAODA Silva… - Anais da Academia …, 2021 - SciELO Brasil
Free radicals are highly reactive unstable molecules, which can be synthesized in different
ways, considered harmful and threatening to humans; these chemical species have free …

Protective capabilities of silymarin and inulin nanoparticles against hepatic oxidative stress, genotoxicity and cytotoxicity of Deoxynivalenol in rats

MA Abdel-Wahhab, AA El-Nekeety, AS Salman… - Toxicon, 2018 - Elsevier
Deoxynivalenol (DON) is a Fusarium mycotoxin that frequently contaminates cereal and
cereal-based food and induces liver injury. This study evaluated the protective role of …

Bioactive compounds from Aspergillus niger extract enhance the antioxidant activity and prevent the genotoxicity in aflatoxin B1-treated rats

MA Abdel-Wahhab, AA El-Nekeety, AS Hathout… - Toxicon, 2020 - Elsevier
This study aimed to identify the bioactive compounds of the ethyl acetate extract of
Aspergillus niger SH2-EGY using GC-MS and to evaluate their protective role against …

Protective effect of procyanidin B2 on acute liver injury induced by aflatoxin B1 in rats

ZJ Deng, JF Zhao, F Huang, GL Sun, GAO Wei… - Biomedical and …, 2020 - Elsevier
Objective This study aimed to explore the protective effect of procyanidin B2 (PCB2) on
acute liver injury induced by aflatoxin B 1 (AFB 1) in rats. Methods Forty Sprague Dawley …

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

P Siupka, FT Hansen, A Schier, S Rocco… - International Journal of …, 2021 - mdpi.com
Crop infections by fungi lead to severe losses in food production and pose risks for human
health. The increasing resistance of pathogens to fungicides has led to the higher usage of …

Costus speciosus extract protects against the oxidative damage of zearalenone via modulation of inflammatory cytokines, Nrf2 and iNOS gene expression in rats

S Gheraibia, N Belattar, KA Diab, ME Hassan… - Toxicon, 2022 - Elsevier
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin that induces severe health
disturbances in humans and animals. This study aimed to determine the bioactive …