Sleep deprivation and neurological disorders

M Bishir, A Bhat, MM Essa, O Ekpo… - BioMed research …, 2020 - Wiley Online Library
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …

BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity

P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

The role of BDNF on neural plasticity in depression

T Yang, Z Nie, H Shu, Y Kuang, X Chen… - Frontiers in cellular …, 2020 - frontiersin.org
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

[PDF][PDF] Brain-derived neurotrophic factor and its clinical implications

S Bathina, UN Das - Archives of medical science, 2015 - termedia.pl
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …

BDNF and hippocampal synaptic plasticity

G Leal, CR Bramham, CB Duarte - Vitamins and hormones, 2017 - Elsevier
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

BDNF and synaptic plasticity, cognitive function, and dysfunction

B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Neurotrophin regulation of neural circuit development and function

H Park, M Poo - Nature Reviews Neuroscience, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

B Lu, G Nagappan, X Guan, PJ Nathan… - Nature Reviews …, 2013 - nature.com
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

Regulation of hippocampal synaptic plasticity by BDNF

G Leal, PM Afonso, IL Salazar, CB Duarte - Brain research, 2015 - Elsevier
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

[HTML][HTML] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

MF Egan, M Kojima, JH Callicott, TE Goldberg… - Cell, 2003 - cell.com
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of …