Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Since March 2013, animal use for cosmetics testing for the European market has been
banned. This requires a renewed view on risk assessment in this field. However, in other …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

Test systems to identify developmental toxicants are urgently needed. A combination of
human stem cell technology and transcriptome analysis was to provide a proof of concept …

Cell-based test methods with a phenotypic readout are frequently used for toxicity screening.
However, guidance on how to validate the hits and how to integrate this information with …

The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a
test battery covering most of the relevant adverse outcome pathways may close this gap …

Medium-to high-throughput in vitro assays that recapitulate the critical processes of nervous
system development have been proposed as a means to facilitate rapid testing and …