The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

The purpose of this expert review is to discuss the impact of nanotechnology in the treatment
of the major health threats including cancer, infections, metabolic diseases, autoimmune …

Purpose: Small cell neuroendocrine carcinoma of the prostate is likely to become
increasingly common with recent advances in pharmacologic androgen suppression. Thus …

The main objective in gene therapy is the development of efficient, non-toxic gene carriers
that can encapsulate and deliver foreign genetic materials into specific cell types such as …

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …

Pathways mediated by p53 and Rb are frequently altered in aggressive human cancers,
including prostate carcinoma. To test directly the roles of p53 and Rb in prostate …

Rapid advances in generating new mouse genetic models for lung neoplasia provide a
continuous challenge for pathologists and investigators. Frequently, phenotypes of new …

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from
calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 …

One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly
into an affected tissue. This requires developing a vehicle which is able to protect the nucleic …

Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …