Critical illnesses and injuries are recognized as major threats to human health, and they are
usually accompanied by uncontrolled inflammation and dysfunction of immune response …

Receptors containing α4 and β2 subunits are a major neuronal nicotinic acetylcholine
receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine …

The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …

Inflammation is a key physiological phenomenon that can be pervasive when dysregulated.
Persistent chronic inflammation precedes several pathophysiological conditions forming one …

Background Compensatory sweating (CS) is a frequent health concern following treatment
of palmar hyperhidrosis using video-assisted thoracoscopic sympathectomy (VATS) and can …

Background: Nicotinic acetylcholine receptors (nAChRs) belong to the Cys-loop ligandgated
ion-channel (LGIC) superfamily, which also includes the GABA, glycine, and serotonin …

The ability of natural enzymes to regulate their guest binding affinities and preferences
through the use of co‐ligands which alter the features of the binding site is fundamental to …

Abstract The low sensitivity (α4) 3 (β2) 2 (LS) and high sensitivity (α4) 2 (β2) 3 (HS) nAChR
isoforms may contribute to a variety of brain functions, pathophysiological processes, and …

Tobacco use is a persistent public health issue. It kills up to half its users and is the cause of
nearly 90% of all lung cancers. The main psychoactive component of tobacco is nicotine …

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have
potential therapeutic application in neuropathologies associated with decrease in function or …