Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

Ischemic stroke is a leading cause of mortality and chronic disability. Either recovery or
progression towards irreversible failure of neurons and astrocytes occurs within minutes to …

Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies
implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor …

Bursting is one of the fundamental rhythms that excitable cells can generate either in
response to incoming stimuli or intrinsically. It has been a topic of intense research in …

Dravet syndrome (DS) is an epileptic encephalopathy that still lacks biomarkers for
epileptogenesis and its treatment. Dysfunction of Na V 1.1 sodium channels, which are …

Within the computational neuroscience community, there has been a focus on simulating the
electrical activity of neurons, while other components of brain tissue, such as glia cells and …

Astrocytes have been in the limelight of active research for about 3 decades now. Over this
period, ideas about their function and role in the nervous system have evolved from simple …

In most neuronal models, ion concentrations are assumed to be constant, and effects of
concentration variations on ionic reversal potentials, or of ionic diffusion on electrical …

Huntington's Disease (HD) is a severe neurodegenerative disorder lacking effective
diagnostic and treatment options. However, there is increasing interest in the potential of …

Epilepsy is an umbrella term used to define a wide variety of seizure disorders and sudden
unexpected death in epilepsy (SUDEP) is the leading cause of death in epilepsy. Although …