During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …

The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …