Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Glioblastoma (GBM) is a devastating human malignancy. GBM stem-like cells (GSCs) drive
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …

Like all cancers, brain tumors require a continuous source of energy and molecular
resources for new cell production. In normal brain, glucose is an essential neuronal fuel, but …

Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is
essentially incurable and its resistance to therapy is attributed to a subpopulation of cells …

Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme,
develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative …

DNA methylation and nucleosome positioning work together to generate chromatin
structures that regulate gene expression. Nucleosomes are typically mapped using …

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here
we show that quiescent, therapy-resistant Sox2+ cells propagate sonic hedgehog subgroup …

Abstract Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial
progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed …

Background The growth and recurrence of several cancers appear to be driven by a
population of cancer stem cells (CSCs). Glioblastoma, the most common primary brain …