Hydrogen sulfide (H 2 S) has profound biological effects within living organisms and is now
increasingly being considered alongside other gaseous signalling molecules, such as nitric …

The αββα metallo β-lactamase (MBL) fold (MBLf) was first observed in bacterial enzymes
that catalyze the hydrolysis of almost all β-lactam antibiotics, but is now known to be widely …

Public health newborn screening (NBS) programs provide population-scale ascertainment
of rare, treatable conditions that require urgent intervention. Tandem mass spectrometry …

Rare diseases are most often caused by inherited genetic disorders that, after translation,
will result in a protein with altered function. Decreased protein stability is the most frequent …

Merely considered as a toxic gas in the past, hydrogen sulfide (H 2 S) is currently viewed as
the third 'gasotransmitter'in addition to nitric oxide (NO) and carbon monoxide (CO), playing …

Reactive persulfide species such as glutathione persulfide (GSSH) are highly abundant
biomolecules. Persulfide dioxygenase (also called ethylmalonic encephalopathy protein 1 …

The kidney is the main organ affected by acute depleted uranium (DU) toxicity. The
mechanism of nephrotoxicity induced by DU is complex and needs to be further explored …

The ethylmalonic encephalopathy protein 1 (ETHE1) catalyses the oxygen-dependent
oxidation of glutathione persulfide (GSSH) to give persulfite and glutathione. Mutations to …

Triple-negative breast cancer (TNBC) is the most fatal subtype of breast cancer; however,
effective treatment strategies for TNBC are lacking. Therefore, it is important to explore the …

Hydrogen sulfide (H 2 S) is a signaling molecule with many beneficial effects. However, its
cellular concentration is strictly regulated to avoid toxicity. Persulfide dioxygenase (PDO or …