Mitochondrial protein import: from proteomics to functional mechanisms

O Schmidt, N Pfanner, C Meisinger - Nature reviews Molecular cell …, 2010 - nature.com
Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …

Translocation of proteins into mitochondria

W Neupert, JM Herrmann - Annu. Rev. Biochem., 2007 - annualreviews.org
Abstract About 10% to 15% of the nuclear genes of eukaryotic organisms encode
mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by …

[HTML][HTML] Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection

S Wang, B He, H Wu, Q Cai, O Ramírez-Sánchez… - Cell Host & Microbe, 2024 - cell.com
Cross-kingdom small RNA trafficking between hosts and microbes modulates gene
expression in the interacting partners during infection. However, whether other RNAs are …

[HTML][HTML] Mitochondrial protein import: common principles and physiological networks

J Dudek, P Rehling, M van der Laan - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

A Chacinska, S Pfannschmidt, N Wiedemann… - The EMBO …, 2004 - embopress.org
Mitochondria import nuclear‐encoded precursor proteins to four different subcompartments.
Specific import machineries have been identified that direct the precursor proteins to the …

[图书][B] The structure of biological membranes

PL Yeagle - 2004 - taylorfrancis.com
Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17

A Chacinska, M Lind, AE Frazier, J Dudek, C Meisinger… - Cell, 2005 - cell.com
The presequence translocase of the inner mitochondrial membrane (TIM23 complex)
operates at a central junction of protein import. It accepts preproteins from the outer …

The protein import machinery of mitochondria

N Wiedemann, AE Frazier, N Pfanner - Journal of Biological Chemistry, 2004 - ASBMB
Most mitochondrial proteins are encoded by nuclear genes and then synthesized as
precursors on cytosolic ribosomes after which they must be imported into the organelle. The …

An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane

V Kozjak, N Wiedemann, D Milenkovic… - Journal of Biological …, 2003 - ASBMB
The preprotein translocase of the outer mitochondrial membrane (TOM complex) contains
one essential subunit, the channel Tom40. The assembly pathway of the precursor of Tom40 …

Mitochondrial import and the twin-pore translocase

P Rehling, K Brandner, N Pfanner - Nature reviews Molecular cell …, 2004 - nature.com
The mitochondrial inner membrane is rich in multispanning integral membrane proteins,
most of which mediate the vital transport of molecules between the matrix and the …