[HTML][HTML] Deciphering the clinical significance of longitudinal antiphospholipid antibody titers

CB Chighizola, R Willis, G Maioli, S Sciascia… - Autoimmunity …, 2024 - Elsevier
In antiphospholipid syndrome (APS), the risk of clinical manifestations increases with higher
titers of antiphospholipid antibodies (aPL). Despite the adoption of aPL titers in the …

Autoimmune diseases affecting hemostasis: a narrative review

EJ Favaloro, L Pasalic, G Lippi - International Journal of Molecular …, 2022 - mdpi.com
Hemostasis reflects a homeostatic mechanism that aims to balance out pro-coagulant and
anti-coagulant forces to maintain blood flow within the circulation. Simplistically, a relative …

[PDF][PDF] Guidelines on the investigation and management of antiphospholipid syndrome

DJ Arachchillage, S Platton, K Hickey, J Chu… - Br J …, 2024 - cancer-networks.com
Review of the guideline followed the standard BSH guidelines procedure. Following review
of the draft guideline by the BSH Haemostasis and Thrombosis Task Force and the BSH …

Lupus Anticoagulant Detection under the Magnifying Glass

AC Molinari, T Martini, L Banov, A Ierardi… - Journal of Clinical …, 2023 - mdpi.com
Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion
(thrombosis and/or pregnancy morbidity), combined with persistently circulating …

Functionally overlapping intra-and extralysosomal pathways promote bis (monoacylglycero) phosphate synthesis in mammalian cells

D Bulfon, J Breithofer, GF Grabner, N Fawzy… - Nature …, 2024 - nature.com
Abstract Bis (monoacylglycero) phosphate (BMP) is a major phospholipid constituent of
intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation …

[HTML][HTML] Added value of antiphosphatidylserine/prothrombin antibodies in the workup of obstetric antiphospholipid syndrome: communication from the ISTH SSC …

A Vandevelde, JC Gris, GW Moore, J Musiał… - Journal of Thrombosis …, 2023 - Elsevier
Background The added value of antiphosphatidylserine/prothrombin antibodies (aPS/PT) in
the diagnostic workup of antiphospholipid syndrome (APS) is unclear. Currently, diagnosis …

Application of the thrombin generation assay in patients with antiphospholipid syndrome: A systematic review of the literature

R Gehlen, A Vandevelde, B de Laat… - Frontiers in …, 2023 - frontiersin.org
Background The antiphospholipid syndrome (APS) is classified by the presence of
antiphospholipid antibodies (aPL) and thrombotic and/or adverse obstetric outcomes. The …

Reporting and Establishment of Reference Intervals for Antiphospholipid Antibody Immunoassays: A Survey of Participants in the College of American Pathologists …

AE Tebo, R Willis, A Nwosu… - … of pathology & …, 2024 - meridian.allenpress.com
Context.—Misdiagnosis of antiphospholipid syndrome can occur owing to the wide diversity
of antiphospholipid (aPL) assays and a lack of international calibrators and harmonized …

Do we need more guidance on thrombophilia testing? Challenges and special considerations

F Marongiu, MF Ruberto, S Marongiu… - Expert Review of …, 2024 - Taylor & Francis
Introduction Thrombophilia testing (TT) is a laboratory procedure designed to detect the risk
factors involved in the pathogenesis of vascular occlusions. The role of TT is also …

Pregnancy and the eye: What do we need to watch out for? A review

R Madike, S Cugati, Q Qin… - Clinical & Experimental …, 2024 - Wiley Online Library
Pregnancy causes changes in all body systems, including the eye. The eye can undergo
physiological and pathological changes in pregnancy. Some changes exacerbate pre …