Recent advance of pH-sensitive nanocarriers targeting solid tumors

T Sim, C Lim, NH Hoang, KT Oh - Journal of Pharmaceutical Investigation, 2017 - Springer
Abstract pH sensitive nanocarriers have showed the tumor targeted drug delivery and
release by enhanced permeability and retention effect and responsiveness of acidic pH …

A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy

C Lim, J Moon, T Sim, WR Won, ES Lee… - Journal of Controlled …, 2019 - Elsevier
Photo-Chemo combination therapy has been intensively investigated for treatment of
cancers, especially multidrug resistance cancer. However, antagonistic interactions between …

Development of a pH-responsive polymer based on hyaluronic acid conjugated with imidazole and dodecylamine for nanomedicine delivery

SM Han, JC Kim, Y Shin, D Lee, T Sim, C Lim… - Macromolecular …, 2022 - Springer
Hyaluronic acid (HA) is being actively studied as a drug carrier due to its favorable
properties and functional groups for chemical modification. Despite its high functionality, p K …

Evaluation and comparison of cytotoxicity, genotoxicity, and apoptotic effects of poly-l-lysine/plasmid DNA micro- and nanoparticles

E Alinejad-Mofrad… - Human & …, 2019 - journals.sagepub.com
The principal impediment to gene therapy is the development of efficient, nontoxic gene
carriers that can handle and deliver foreign genetic materials into various cell types …

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

T Sim, C Lim, NH Hoang, Y Shin, JC Kim, JY Park… - Pharmaceutics, 2020 - mdpi.com
Combination therapy is considered to be a promising strategy for improving the therapeutic
efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) …

[HTML][HTML] " Grafting-from" synthesis and characterization of poly (2-ethyl-2-oxazoline)-b-poly (benzyl L-glutamate) micellar nanoparticles for potential biomedical …

M Salmanpour, A Tamaddon, G Yousefi… - BioImpacts …, 2017 - ncbi.nlm.nih.gov
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Introduction: Recent advances in the field of poly (2-oxazolines) as bio-inspired synthetic …

Co-delivery of d-(KLAKLAK) 2 peptide and doxorubicin using a pH-sensitive nanocarrier for synergistic anticancer treatment

C Lim, WR Won, J Moon, T Sim, Y Shin… - Journal of Materials …, 2019 - pubs.rsc.org
Currently, one of the most important challenges in the development of nanotechnology-
based anticancer treatments is the failure of nanoparticles to escape from the endo …

Self-assembled polymeric micelles for targeted photodynamic therapy of human epidermal growth factor receptor 2 overexpressing breast cancer

YJ Kim, JH Ha, YJ Kim - Nanotechnology, 2021 - iopscience.iop.org
Photodynamic therapy (PDT) has been extensively explored as a promising alternative
therapeutic approach for many malignant tumors. However, the PDT system generally …

A pH-sensitive polymer for cancer targeting prepared by one-step modulation of functional side groups

T Sim, SM Han, C Lim, WR Won, ES Lee… - Macromolecular …, 2019 - Springer
Nanocarriers with pH-sensitive functionality are of great interest in the development of pH-
dependent drug release compounds in acidic tumor microenvironments. A new …

A charge-reversible nanocarrier using PEG-PLL (-g-Ce6, DMA)-PLA for photodynamic therapy

C Lim, T Sim, NH Hoang, CE Jung, ES Lee… - International Journal …, 2017 - Taylor & Francis
A polyelectrolyte nanoparticle composed of PEG-PLL (-g-Ce6, DMA)-PLA was developed for
nanomedicinal application in photodynamic therapy. These nanoparticles formed stable …