Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Objective Accumulating evidence links the intestinal microbiota and colorectal
carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and …

Since genetic and epigenetic alterations influence the development of colorectal cancer
(CRC), huge potential lies in the use of DNA methylation as biomarkers to improve the …

Colorectal cancer (CRC) is one of the most common malignant diseases worldwide, but the
involved signaling pathways and driven-genes are largely unclear. This study integrated …

Colorectal cancer (CRC) is one of the most common human malignancies accounting for
approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is …

Colorectal cancers (CRCs) are the third leading cause of cancer-related mortality worldwide.
Rather than being a single, uniform disease type, accumulating evidence suggests that …

Colorectal Cancer (CRC) is the third most prevalent cancer in men and women. Up to 15%
of CRCs display microsatellite instability (MSI). MSI is reflective of a deficient mismatch …

Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Aberrant DNA methylation is a fundamental characterization of epigenetics for
carcinogenesis. Abnormality of DNA methylation-related functional elements (DMFEs) may …