Many tumors have well-defined vulnerabilities, thus potentially allowing highly specific and
effective treatment. There is a spectrum of actionable genetic alterations which are shared …

The management of lung cancer (LC) requires the analysis of a diverse spectrum of
molecular targets, including kinase activating mutations in EGFR, ERBB2 (HER2), BRAF …

The majority of NTRK1, NTRK2, and NTRK3 rearrangements result in increased expression
of the kinase portion of the involved gene due to its fusion to an actively transcribed gene …

This study aimed to conduct a comprehensive analysis of actionable gene rearrangements
in tumors with microsatellite instability (MSI). The detection of translocations involved tests …

The technique 3'rapid amplification of cDNA ends (3′ RACE) allows for detection of
translocations with unknown gene partners located at the 3′ end of the chimeric transcript …

Background Selpercatinib, a selective RET kinase inhibitor, is approved for treating various
cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small …

Systemic chemotherapy is the main treatment option for patients with advanced intrahepatic
cholangiocarcinoma (iCCA), however, its efficacy is limited. Herein, we report a young …