Micropatterning encompasses a set of methods aimed at precisely controlling the spatial
distribution of molecules onto the surface of materials. Biologists have borrowed the idea …

Chemically defined hydrogels are increasingly utilized to define the effects of extracellular
matrix (ECM) components on cellular fate determination of human embryonic and induced …

Background Extensive studies have revealed the function and mechanism of lncRNAs in
development and differentiation, but the majority have focused on those lncRNAs adjacent …

Abstract Background Paired box 1 (PAX1) is a transcription factor and essential for the
development of pharyngeal pouches-derived tissues, including thymus. PAX1 mutations are …

Human induced pluripotent stem cells (hiPSCs) are promising resources for producing
various types of tissues in regenerative medicine; however, the improvement in a scalable …

Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the
generation of diverse organ-like structures. In this study, we used the small molecule …

The regulatory network between signaling pathways and transcription factors (TFs) is crucial
for the maintenance of pluripotent stem cells. However, little is known about how the key TF …

Though gains of chromosome 12p13. 31 are highly recurrent in hPSC, their impact on
differentiation is poorly understood. We identify a reduction in differentiation capacity …

Pluripotent stem cells (PSCs) are increasingly utilized to investigate early human
developmental processes including gastrulation and organogenesis of endoderm-derived …