Mechanisms of environmental contributions to fatty liver disease
Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
Evolutionary Physiology and Genomics in the Highly Adaptable Killifish (Fundulus heteroc
DL Crawford - Comprehensive Physiology, 2020 - par.nsf.gov
By investigating evolutionary adaptations that change physiological functions, we can
enhance our understanding of how organisms work, the importance of physiological traits …
enhance our understanding of how organisms work, the importance of physiological traits …
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery
K Wuputra, MH Tsai, K Kato, CC Ku, JB Pan… - Inflammation and …, 2023 - Springer
Background Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor
(erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which …
(erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which …
Aryl hydrocarbon receptor mediates benzo [a] pyrene-induced metabolic reprogramming in human lung epithelial BEAS-2B cells
G Ye, H Gao, X Zhang, X Liu, J Chen, X Liao… - Science of the Total …, 2021 - Elsevier
Polycyclic aromatic hydrocarbon exposure accelerates the initiation and progression of lung
cancer through aryl hydrocarbon receptor (AHR) signaling. Metabolic reprogramming is a …
cancer through aryl hydrocarbon receptor (AHR) signaling. Metabolic reprogramming is a …
Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo [a] …
Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic for which environmental
contaminants are increasingly recognized as important etiological factors. Among them, the …
contaminants are increasingly recognized as important etiological factors. Among them, the …
Prediction model of aryl hydrocarbon receptor activation by a novel qsar approach, deepsnap–deep learning
Y Matsuzaka, T Hosaka, A Ogaito, K Yoshinari… - Molecules, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that senses
environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular …
environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular …
Integrated metabolomic and transcriptomic analysis identifies benzo [a] pyrene-induced characteristic metabolic reprogramming during accumulation of lipids and …
G Ye, W Lu, L Zhang, H Gao, X Liao, X Zhang… - Science of The Total …, 2022 - Elsevier
Polycyclic aromatic hydrocarbon exposure is a major risk factor for cardiovascular diseases.
Macrophage lipid accumulation is a characteristic molecular event in the pathophysiology of …
Macrophage lipid accumulation is a characteristic molecular event in the pathophysiology of …
TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule
The persistent environmental aryl hydrocarbon receptor agonist and hepatotoxin TCDD (2,
3, 7, 8-tetrachlorodibenzo-p-dioxin) induces hepatic lipid accumulation (steatosis) …
3, 7, 8-tetrachlorodibenzo-p-dioxin) induces hepatic lipid accumulation (steatosis) …
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor
(AhR) agonist that elicits a broad spectrum of dose-dependent hepatic effects including lipid …
(AhR) agonist that elicits a broad spectrum of dose-dependent hepatic effects including lipid …
Polybrominated dibenzo-p-dioxins (PBDDs) and–dibenzofurans (PBDFs) in cod (Gadus morhua) liver-derived products from 1972 to 2017
J Falandysz, F Smith, AR Fernandes - Science of The Total Environment, 2020 - Elsevier
Literature data on the occurrence and prevalence of polybrominated dibenzo-p-dioxins
(PBDDs) and polybrominated dibenzofurans (PBDFs) in foods including seafood are scarce …
(PBDDs) and polybrominated dibenzofurans (PBDFs) in foods including seafood are scarce …