Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …

Background The major challenge for obstetrics is the prediction and prevention of the great
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …

The importance of a fully functioning placenta for a good pregnancy outcome is
unquestioned. Loss of function can lead to pregnancy complications and is often detected by …

BACKGROUND: Obesity is a well-established risk factor for both adverse pregnancy
outcomes (APOs) and cardiovascular disease (CVD). However, it is not known whether …

Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …

BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …

The human placenta is a poorly-understood organ, but one that is critical for proper
development and growth of the fetus in-utero. The epithelial cell type that contributes to …

Fetal growth restriction (FGR) leading to low birth weight (LBW) is a major cause of neonatal
morbidity and mortality worldwide. Normal placental development involves a series of highly …

Background Spontaneous preterm birth accounts for most preterm births and leads to
significant morbidity in the newborn and childhood period. This subtype of preterm birth …