Recent advances in fluorescence imaging permit large-scale recording of neural activity and
dynamics of neurochemical release with unprecedented resolution in behaving animals …

Despite decades of research on the neurobiology of major depressive disorder (MDD), the
mechanisms underlying its expression remain unknown. The medial prefrontal cortex …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

Environmental cues influence the highly dynamic morphology of microglia. Strategies to
characterize these changes usually involve user-selected morphometric features, which …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Proteomic profiling of brain cell types using isolation-based strategies pose limitations in
resolving cellular phenotypes representative of their native state. We describe a mouse line …

Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an
approach to generate human neurons for disease modeling. However, programming …

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …

Alterations in upper motor neuron excitability are one of the earliest phenomena clinically
detected in ALS, and in 97% of cases, the RNA/DNA binding protein, TDP-43, is …