Small and long non-coding RNAs: Past, present, and future
LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
CircRNA and lncRNA-encoded peptide in diseases, an update review
Q Yi, J Feng, W Lan, H Shi, W Sun, W Sun - Molecular Cancer, 2024 - Springer
Abstract Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs) and long non-
coding RNAs (lncRNAs), are unique RNA molecules widely identified in the eukaryotic …
coding RNAs (lncRNAs), are unique RNA molecules widely identified in the eukaryotic …
LncRNA-encoded peptides in cancer
Y Zhang - Journal of Hematology & Oncology, 2024 - Springer
Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as
critical regulators of gene expression and key players in cancer biology. Recent …
critical regulators of gene expression and key players in cancer biology. Recent …
A hybrid quantum computing pipeline for real world drug discovery
W Li, Z Yin, X Li, D Ma, S Yi, Z Zhang, C Zou, K Bu… - Scientific Reports, 2024 - nature.com
Quantum computing, with its superior computational capabilities compared to classical
approaches, holds the potential to revolutionize numerous scientific domains, including …
approaches, holds the potential to revolutionize numerous scientific domains, including …
Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
G Yin, J Huang, J Petela, H Jiang, Y Zhang… - Signal transduction and …, 2023 - nature.com
Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …
Current understanding of functional peptides encoded by lncRNA in cancer
H Tian, L Tang, Z Yang, Y Xiang, Q Min, M Yin… - Cancer Cell …, 2024 - Springer
Dysregulated gene expression and imbalance of transcriptional regulation are typical
features of cancer. RNA always plays a key role in these processes. Human transcripts …
features of cancer. RNA always plays a key role in these processes. Human transcripts …
Microproteins in cancer: identification, biological functions, and clinical implications
Cancer continues to be a major global health challenge, accounting for 10 million deaths
annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 …
annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 …
Connecting the dots: LncRNAs in the KRAS pathway and cancer
Long non-coding RNAs (lncRNAs) have been identified as important participants in several
biological functions, particularly their complex interactions with the KRAS pathway, which …
biological functions, particularly their complex interactions with the KRAS pathway, which …
A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit …
S Zhai, J Lin, Y Ji, R Zhang, Z Zhang, Y Cao, Y Liu… - Cell Discovery, 2023 - nature.com
The extensively activated Notch signaling pathway in pancreatic cancer cells is important in
carcinogenesis, chemoresistance, and recurrence. Targeting this pathway is a promising …
carcinogenesis, chemoresistance, and recurrence. Targeting this pathway is a promising …
Investigating underlying molecular mechanisms, signaling pathways, emerging therapeutic approaches in pancreatic cancer
Pancreatic adenocarcinoma, a clinically challenging malignancy constitutes a significant
contributor to cancer-related mortality, characterized by an inherently poor prognosis. This …
contributor to cancer-related mortality, characterized by an inherently poor prognosis. This …