The circadian immune system
C Wang, LK Lutes, C Barnoud, C Scheiermann - Science immunology, 2022 - science.org
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …
the first to identify immune responses to be under a circadian control. Only in the last …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Clocking in to immunity
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …
diversity of physiological systems. It has long been established that the circadian clockwork …
[HTML][HTML] Perfect timing: circadian rhythms, sleep, and immunity—an NIH workshop summary
JA Haspel, R Anafi, MK Brown, N Cermakian… - JCI insight, 2020 - ncbi.nlm.nih.gov
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …
Circadian rhythm influences induction of trained immunity by BCG vaccination
LCJ de Bree, VP Mourits… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND The antituberculosis vaccine bacillus Calmette-Guérin (BCG) reduces
overall infant mortality. Induction of innate immune memory, also termed trained immunity …
overall infant mortality. Induction of innate immune memory, also termed trained immunity …
[HTML][HTML] Molecular interactions between components of the circadian clock and the immune system
S Hergenhan, S Holtkamp, C Scheiermann - Journal of molecular biology, 2020 - Elsevier
The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …
observed in the immune system originate in direct interactions between components of the …
The REV-ERB nuclear receptors: timekeepers for the core clock period and metabolism
M Adlanmerini, MA Lazar - Endocrinology, 2023 - academic.oup.com
REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …
Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients
BACKGROUND Circadian rhythms are evident in basic immune processes, but it is unclear
if rhythms exist in clinical endpoints like vaccine protection. Here, we examined associations …
if rhythms exist in clinical endpoints like vaccine protection. Here, we examined associations …
The circadian clock and viral infections
H Borrmann, JA McKeating… - Journal of biological …, 2021 - journals.sagepub.com
The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …
[HTML][HTML] Time-of-day-dependent trafficking and function of leukocyte subsets
The number of leukocytes circulating in blood in mammals is under circadian control (ie,∼
24h). We summarize here latest findings on the mechanisms governing leukocyte migration …
24h). We summarize here latest findings on the mechanisms governing leukocyte migration …