Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Correct expression of specific sets of genes in time and space ensures the establishment
and maintenance of cell identity, which is required for proper development of multicellular …

The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …

Germ cells are the special cells in the body that undergo meiosis to generate gametes and
subsequently entire new organisms after fertilization, a process that continues generation …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Plant ontogeny relies on the correct timing and sequence of transitions between individual
developmental phases. These are specified by gene expression patterns that are …

Transcription is well known to be inherently stochastic and episodic, but the regulation of
transcriptional dynamics is not well understood. Here, we analyze how Notch signaling …

Chromatin is organized and compacted in the nucleus through the association of histones
and other proteins, which together control genomic activity. Two broad types of chromatin …