Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis.
Herein we show that tissue-resident interstitial macrophages (Res-TAMs) in mouse lungs …

Alveolar macrophages are the most abundant innate immune cells in the distal lung
parenchyma, located on the luminal surface of the alveolar space. They are the first to …

Metastatic cancers produce exosomes that condition pre-metastatic niches in remote
microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly …

Resident tissue macrophages (RTM) can fulfill various tasks during development,
homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial …

Lung complications are a major cause of rheumatoid arthritis-related mortality. Involvement
of gut microbiota in lung diseases by the gut-lung axis has been widely observed, but the …

Neutrophil migration to injured and pathogen-infected tissues is a fundamental component
of innate immunity. An array of cellular and molecular events mediate this response to …

Tumors of various histological origins show abundant infiltration of myeloid cells from early
stages of disease progression. These cells have a profound impact on antitumor immunity …

Monocytes are a subset of cells that are categorized together with dendritic cells (DCs) and
macrophages in the mononuclear phagocyte system (MPS). Despite sharing several …