Choroidal mast cells and pathophysiology of age-related macular degeneration
Age-related macular degeneration (AMD) remains a leading cause of vision loss in elderly
patients. Its etiology and progression are, however, deeply intertwined with various cellular …
patients. Its etiology and progression are, however, deeply intertwined with various cellular …
[HTML][HTML] Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: reversing mitochondrial …
Diabetic retinopathy (DR) is a major cause of blindness in adult, and the accumulation of
advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal …
advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal …
Regulated cell death pathways in the sodium iodate model: Insights and implications for AMD
M Upadhyay, VL Bonilha - Experimental Eye Research, 2023 - Elsevier
The sodium iodate (NaIO 3) model of increased oxidative stress recapitulates dry AMD
features such as patchy RPE loss, secondary photoreceptors, and underlying …
features such as patchy RPE loss, secondary photoreceptors, and underlying …
NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1
YL Huang, DY Huang, V Klochkov, CM Chan, YS Chen… - Antioxidants, 2024 - mdpi.com
The activation of microglia and the production of cytokines are key factors contributing to
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …
P2X7 receptors: a bibliometric review from 2002 to 2023
H Tang, W Wei, Y Luo, X Lu, J Chen, S Yang, F Wu… - Purinergic …, 2024 - Springer
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A
comprehensive, systematic, and objective evaluation of the scientific output and status of …
comprehensive, systematic, and objective evaluation of the scientific output and status of …
[HTML][HTML] Protective effects of CY-09 and astaxanthin on NaIO3-induced photoreceptor inflammation via the NLRP3/autophagy pathway
XL Wang, YX Gao, QZ Yuan… - International Journal of …, 2024 - ncbi.nlm.nih.gov
AIM To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory
response and the protective mechanism of CY-09 and astaxanthin (AST). METHODS ICR …
response and the protective mechanism of CY-09 and astaxanthin (AST). METHODS ICR …
Microglial mechanisms of cell death and the role of the P2X7 receptor in relation to glaucoma
J Newman - 2023 - ueaeprints.uea.ac.uk
Purpose: The purpose of this research was to investigate mechanisms of cell death in
microglia in the context of neurodegenerative disease including glaucoma. The effects of …
microglia in the context of neurodegenerative disease including glaucoma. The effects of …