Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
How transcription factors drive choice of the T cell fate
H Hosokawa, EV Rothenberg - Nature Reviews Immunology, 2021 - nature.com
Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …
in the thymus and undergo commitment to become T cells. Together with environmental …
Chromatin states define tumour-specific T cell dysfunction and reprogramming
M Philip, L Fairchild, L Sun, EL Horste, S Camara… - Nature, 2017 - nature.com
Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability …
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability …
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia
Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …
CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
K Hirahara, T Nakayama - International immunology, 2016 - academic.oup.com
CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …
Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
Macrophages provide a critical systemic network cells of the innate immune system.
Emerging data suggest that in addition, they have important tissue-specific functions that …
Emerging data suggest that in addition, they have important tissue-specific functions that …
Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer-promoter communication and T cell fate
It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search …
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search …
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage
JA Wamstad, JM Alexander, RM Truty, A Shrikumar… - Cell, 2012 - cell.com
Heart development is exquisitely sensitive to the precise temporal regulation of thousands of
genes that govern developmental decisions during differentiation. However, we currently …
genes that govern developmental decisions during differentiation. However, we currently …
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
When B cells encounter an antigen, they alter their physiological state and anatomical
localization and initiate a differentiation process that ultimately produces antibody-secreting …
localization and initiate a differentiation process that ultimately produces antibody-secreting …