Antibody-mediated rejection (ABMR) in organ transplantation has been recognized as the
main cause of graft rejection. Binding of donor-specific HLA antibody (DSA) and A/B blood …

The ability to personalize management for a given kidney transplant recipient and identify
treatments that will improve their long-term outcome remains a critical unmet need. Earlier …

In organ transplantation, infection and rejection are major causes of graft loss. They are
linked by the net state of immunosuppression. To diagnose and treat these conditions …

Despite the critical role of cytokines in allograft rejection, the relation of peripheral blood
cytokine profiles to clinical kidney transplant rejection has not been fully elucidated. We …

Remarkable advances have been made in the pathophysiology, diagnosis, and treatment of
antibody-mediated rejection (ABMR) over the past decades, leading to improved graft …

Kidney transplantation causes large perturbations of the immune system. While many
studies focus on the allograft, insights into systemic effects are largely missing. Here, we …

Solid phase immunoassays improved the detection and determination of the antigen-
specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The …

Antibody mediated transplant rejection (AMR) is a major cause of long-term allograft failure,
and currently available treatments are of limited efficacy for treating the disease. AMR is …

Kidney transplant patients require careful management of immunosuppression to avoid
rejection while minimizing the risk of infection and malignancy for the best long-term …

The interplay between donor‐specific anti‐HLA antibodies (HLA‐DSA), histology of active
antibody‐mediated rejection (aABMRh), transplant glomerulopathy (cg), and graft failure in …