This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …

Pharmaceutical analysis refers to an area of analytical chemistry that deals with active
compounds either by themselves (drug substance) or when formulated with excipients (drug …

Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of
biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential …

Local drug delivery to the eye through conventional means has faced many challenges due
to three essential barriers:(a) the complex structure of the cornea limiting drug absorption,(b) …

The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a
common laboratory model to study ocular toxicity, combining both fish and vertebrate …

Cataract is a leading cause of blindness globally, and its surgical treatment poses a
significant burden on global healthcare. Pharmacologic therapies, including antioxidants …

Recently, cGMP analogues have been investigated for the treatment of inherited retinal
degenerations (IRD) using intravitreal injections. However, higher vitreous elimination rates …

Cyclosporine A (CsA) as an eye drop is an effective treatment for dry eye. However, it has
potential side effects and a short ocular residence time. To overcome these obstacles, we …

The nuclear region of the lens is metabolically quiescent, but it is far from inert chemically.
Without cellular renewal and with decades of environmental exposures, the lens proteome …