Reactive oxygen species (ROS) are produced mainly by mitochondrial respiration and
function as signaling molecules in the physiological range. However, ROS production is also …

Inborn errors of metabolism (IEMs) are a group of monogenic disorders characterized by
dysregulation of the metabolic networks that underlie development and homeostasis …

Background The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-
methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of leucine and isovaleric …

We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal
subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise …

Although circulating DNA (cirDNA) analysis shows great promise as a screening tool for a
wide range of pathologies, numerous stumbling blocks hinder the rapid translation of …

Purpose Prostate cancer (PCa) is the most common cancer in American men, and the
mechanisms of development and progression are still not completely clear. Methylcrotonoyl …

Aim: Methylcrotonoyl-CoA carboxylase 2 (MCCC2), a subunit of 3-Methylcrotonyl-CoA
carboxylase (MCC), is reported to be involved in tumor formation and development …

Zebra mussel (ZM), Dreissena polymorpha, commonly used as a sentinel species in
freshwater biomonitoring, is now in competition for habitat with quagga mussel (QM) …

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid
starvation response as well as the ribotoxic stress response. We previously demonstrated …

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of
mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially …