Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Generating active, pure, and monodisperse protein remains a major bottleneck for structural
studies using X‐ray crystallography and cryo‐electron microscopy (cryo‐EM). The current …

Intraflagellar transport (IFT) trains, the polymers composed of two multi-subunit complexes,
IFT-A and IFT-B, carry out bidirectional intracellular transport in cilia, vital for cilia biogenesis …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

Owing to their crucial roles in development and homeostasis, defects in cilia cause
ciliopathies with diverse clinical manifestations. The intraflagellar transport (IFT) machinery …

Ciliopathies are inherited disorders caused by defective cilia. Mutations affecting motile cilia
usually cause the chronic muco-obstructive sinopulmonary disease primary ciliary …

Intraflagellar transport (IFT) trains, built around IFT-A and IFT-B complexes, are carried by
opposing motors to import and export ciliary cargo. While transported by kinesin-2 on …

Ciliary transport in eukaryotic cells is an intricate and conserved process involving the
coordinated assembly and functioning of a multiprotein intraflagellar transport (IFT) complex …

The primary cilium is a dynamic subcellular compartment templated from the mother
centriole or basal body. Cilia are solitary and tiny, but remarkably consequential in cellular …

Primary cilia in brain neurons provide a privileged compartment for binding and responding
to extracellular ligands such as sonic hedgehog. Paradoxically, cilia in differentiating …