Techniques of assessing small airways dysfunction

W McNulty, OS Usmani - European clinical respiratory journal, 2014 - Taylor & Francis
The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Hyperpolarized 3He and 129Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease

M Kirby, S Svenningsen, A Owrangi, A Wheatley… - Radiology, 2012 - pubs.rsna.org
Purpose To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe)
magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and …

Hyperpolarized 3He magnetic resonance functional imaging semiautomated segmentation

M Kirby, M Heydarian, S Svenningsen, A Wheatley… - Academic radiology, 2012 - Elsevier
RATIONALE AND OBJECTIVES: To improve intra-and interobserver variability and enable
the use of functional magnetic resonance imaging (MRI) for multicenter, multiobserver …

Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5T

NJ Stewart, HF Chan, PJC Hughes… - Journal of magnetic …, 2018 - Wiley Online Library
Background To support translational lung MRI research with hyperpolarized 129Xe gas,
comprehensive evaluation of derived quantitative lung function measures against …

New and current clinical imaging techniques to study chronic obstructive pulmonary disease

HO Coxson, J Mayo, S Lam, G Santyr… - American journal of …, 2009 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized
by both small airway and parenchymal abnormalities. There is increasing evidence to …

Multi-nuclear magnetic resonance spectroscopy: State of the art and future directions

Y Wei, C Yang, H Jiang, Q Li, F Che, S Wan, S Yao… - Insights into …, 2022 - Springer
With the development of heteronuclear fluorine, sodium, phosphorus, and other probes and
imaging technologies as well as the optimization of magnetic resonance imaging (MRI) …

Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease

RS Virgincar, ZI Cleveland… - NMR in …, 2013 - Wiley Online Library
In this study, hyperpolarized 129Xe MR ventilation and 1H anatomical images were
obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic …

Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report

CCW Hsia, JHT Bates, B Driehuys, SB Fain… - Annals of the …, 2023 - atsjournals.org
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Chronic Obstructive Pulmonary Disease: Longitudinal Hyperpolarized 3He MR Imaging

M Kirby, L Mathew, A Wheatley, GE Santyr… - Radiology, 2010 - pubs.rsna.org
Purpose To quantitatively evaluate a small pilot group of ex-smokers with chronic obstructive
pulmonary disease (COPD) and healthy volunteers during approximately 2 years by using …