The prefrontal cortex, pathological anxiety, and anxiety disorders

MM Kenwood, NH Kalin, H Barbas - Neuropsychopharmacology, 2022 - nature.com
Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery

SE Grogans, E Bliss-Moreau, KA Buss, LA Clark… - Neuroscience & …, 2023 - Elsevier
Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …

[PDF][PDF] Inducing anxiety in large language models increases exploration and bias

J Coda-Forno, K Witte, AK Jagadish… - arXiv preprint arXiv …, 2023 - hcai-munich.com
Large language models are transforming research on machine learning while galvanizing
public debates. Understanding not only when these models work well and succeed but also …

Space, time, and fear: survival computations along defensive circuits

D Mobbs, DB Headley, W Ding, P Dayan - Trends in cognitive sciences, 2020 - cell.com
Naturalistic observations show that decisions to avoid or escape predators occur at different
spatiotemporal scales and that they are supported by different computations and neural …

[HTML][HTML] Fear and anxiety in the face of COVID-19: Negative dispositions towards risk and uncertainty as vulnerability factors

P Millroth, R Frey - Journal of Anxiety Disorders, 2021 - Elsevier
In the face of the COVID-19 pandemic it is important to identify factors that make people
particularly vulnerable of developing mental-health issues in order to provide case-specific …

[HTML][HTML] Uncertainty as a driver of the youth mental health crisis

S Schweizer, RP Lawson, SJ Blakemore - Current Opinion in Psychology, 2023 - Elsevier
Mental health problems in young people have been on the rise for over a decade, with that
trend accelerating during the pandemic. This review proposes that the catalyst effect of the …

The relationships between stress, mental disorders, and epigenetic regulation of BDNF

Z Miao, Y Wang, Z Sun - International journal of molecular sciences, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays
an important role in multiple stress-related mental disorders. Although alterations in BDNF in …

Investigation on the mental health status of pregnant women in China during the Pandemic of COVID-19

H Dong, R Hu, C Lu, D Huang, D Cui, G Huang… - Archives of gynecology …, 2021 - Springer
Purpose To evaluate the anxiety and depression in pregnant women in China, and its
influencing factors during the corona virus disease 2019 (COVID-19) pandemic. Methods …

Advances in modeling learning and decision-making in neuroscience

AGE Collins, A Shenhav - Neuropsychopharmacology, 2022 - nature.com
An organism's survival depends on its ability to learn about its environment and to make
adaptive decisions in the service of achieving the best possible outcomes in that …

A neural substrate of sex-dependent modulation of motivation

J Cox, AR Minerva, WT Fleming, CA Zimmerman… - Nature …, 2023 - nature.com
While there is emerging evidence of sex differences in decision-making behavior, the neural
substrates that underlie such differences remain largely unknown. Here we demonstrate that …