Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

Inflammation is a complex process which is highly conserved among species. Inflammation
occurs in response to injury, infection, and cancer, as an allostatic mechanism to return the …

For many decades, glucocorticoids have been widely used as the gold standard treatment
for inflammatory conditions. Unfortunately, their clinical use is limited by severe adverse …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …

Binding of different ligands to glucocorticoid receptor (GR) may induce different
conformational changes and even trigger completely opposite biological functions. To …

Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action
are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated …

Glucocorticoids (GCs), steroid hormones that depend on glucocorticoid receptor (GR)
binding for their action, are essential for regulating numerous homeostatic functions in the …

The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator
is required only for a subset of the genes regulated by a specific transcription factor. These …

The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections
are poorly understood. To uncover these events, we performed transcriptome analyses of …