The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

Asthma is a chronic inflammatory disease of the airway with extensive airway remodeling.
The ethical issues associated with the studies in asthmatic patients, required development of …

There is emerging evidence that stem cells can rejuvenate damaged cells by mitochondrial
transfer. Earlier studies show that epithelial mitochondrial dysfunction is critical in asthma …

BACKGROUND: Exosomes are nanovesicles involved in intercellular communication. Their
roles in various diseases are often contextual, depending on the cell type producing them …

Dynamic variations in mitochondrial shape have been related to function. However, tools to
automatically classify and enumerate mitochondrial shapes are lacking, as are systematic …

There is growing epidemiological evidence that obesity increases the risk of developing
asthma. In some studies, insulin resistance or metabolic syndrome is a stronger risk factor …

Altered bioenergetics with increased mitochondrial reactive oxygen species production and
degradation of epithelial function are key aspects of pathogenesis in asthma and chronic …

Rationale: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase
(NOS) inhibitor that competes with l-arginine for binding to NOS. It has been suggested that …

Asthma remains a major health problem with significant morbidity, mortality and economic
costs. In asthma, airway remodelling, which refers to all the microscopic structural changes …

Background: Simvastatin is a cholesterol‐lowering drug whose pleiotropic effects may have
a therapeutic impact on bone. This study evaluates the effect of simvastatin on rats subjected …