Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

Cerebral cortex size differs dramatically between reptiles, birds, and mammals, owing to
developmental differences in neuron production. In mammals, signaling pathways …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino
group of an N-terminal glycine residue of many eukaryotic and viral proteins. The ubiquitous …

Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local
protein synthesis, is the mouse homolog of ApCPEB, a functional prion protein in Aplysia …

Notch receptors are transmembrane receptors that regulate cell fate decisions. There are
four Notch receptors in mammals. Upon binding to members of the Delta and Jagged family …

Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that
optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling …