Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Critical-size bone defects, which require large-volume tissue reconstruction, remain a
clinical challenge. Bone engineering has the potential to provide new treatment concepts …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Kidneys are highly vascular organs that despite their relatively small size receive 20% of the
cardiac output. The highly intricate, delicately organized structure of renal microcirculation is …

Background Acute kidney injury (AKI) is a frequent and serious complication after aortic
surgery requiring cardiopulmonary bypass (CPB). Dexmedetomidine, a selective α-2 …

Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …

While extensive research using animal models has improved the understanding of acute
kidney injury (AKI), this knowledge has not been translated into effective treatments. Many …