Extrasynaptic GABAA receptors: their function in the CNS and implications for disease
SG Brickley, I Mody - Neuron, 2012 - cell.com
Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …
populations that enable neurons to sense the low ambient GABA concentrations present in …
Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network …
Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
Abstract γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis
PL Brooks, JH Peever - Journal of Neuroscience, 2012 - Soc Neuroscience
During REM sleep the CNS is intensely active, but the skeletal motor system is paradoxically
forced into a state of muscle paralysis. The mechanisms that trigger REM sleep paralysis are …
forced into a state of muscle paralysis. The mechanisms that trigger REM sleep paralysis are …
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain,
but its role in sensory information processing remains poorly understood. The cerebellum is …
but its role in sensory information processing remains poorly understood. The cerebellum is …
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency
Individuals with glucose transporter type I deficiency (G1D) habitually experience nutrient-
responsive epilepsy associated with decreased brain glucose. However, the mechanistic …
responsive epilepsy associated with decreased brain glucose. However, the mechanistic …
The ubiquitous nature of multivesicular release
'Simplicity is prerequisite for reliability'(EW Dijkstra [1]) Presynaptic action potentials trigger
the fusion of vesicles to release neurotransmitter onto postsynaptic neurons. Each release …
the fusion of vesicles to release neurotransmitter onto postsynaptic neurons. Each release …
GABA-independent GABAA receptor openings maintain tonic currents
AI Wlodarczyk, S Sylantyev, MB Herd… - Journal of …, 2013 - Soc Neuroscience
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: phasic
inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic …
inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic …
Regulation of GABAA Receptor Subunit Expression in Substance Use Disorders
JS Barker, RM Hines - International Journal of Molecular Sciences, 2020 - mdpi.com
The modulation of neuronal cell firing is mediated by the release of the neurotransmitter
GABA (γ-aminobuytric acid), which binds to two major families of receptors. The ionotropic …
GABA (γ-aminobuytric acid), which binds to two major families of receptors. The ionotropic …
Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice
The central nucleus of the amygdala (CeA) is an important integrative site for the reinforcing
effects of drugs of abuse, such as ethanol. Activation of corticotropin-releasing factor type 1 …
effects of drugs of abuse, such as ethanol. Activation of corticotropin-releasing factor type 1 …