It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Recent findings of diverse populations of prion-like conformers of misfolded tau protein
expand the prion concept to Alzheimer's disease (AD) and monogenic frontotemporal lobar …

Amyloid deposition of the microtubule-associated protein tau is associated with
neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau) …

Heterozygous hTau mice were used for the study of tau seeding. These mice express the six
human tau isoforms, with a high predominance of 3Rtau over 4Rtau. The following groups …

The aberrant accumulation of tau protein is implicated as a pathogenic factor in many
neurodegenerative diseases. Tau seeding may underlie its predictable spread in these …

Neurodegenerative diseases represent a large group of disorders characterized by gradual
loss of neurons and functions of the central nervous systems. Their course is usually severe …

Ageing is the greatest risk factor of late‐onset neurodegenerative diseases. In the realm of
sporadic tauopathies, modelling the process of biological ageing in experimental animals …

Tauopathies are a group of neurodegenerative diseases characterized by the
hyperphosphorylation and deposition of tau proteins in the brain. In Alzheimer's disease …

Nattokinase, from the Japanese fermented food natto, is a protease with fibrinolytic activity
that can thus degrade conventional blood clots. In some cases, however, including in Long …

Protein misfolding has been extensively studied in the context of neurodegenerative
disorders and systemic amyloidoses. Due to misfolding and aggregation of proteins being …