Gliomas are highly invasive and are the most common type of primary malignant brain
tumor. The routine treatments for glioma include surgical resection, radiotherapy, and …

Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is
dismally characterized by a very poor prognosis. Thus, the search of new, more effective …

The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours
classification has transformed the pathological diagnosis of gliomas from purely histological …

Abstract The IDH1-R132H mutation is implicated in the development of various tumors.
Whether cisplatin, a common chemotherapeutic agent, induces more significant renal …

Background Only a small group of patients with glioblastoma multiforme (GBM) survives
more than 36 months, so-called long-term survivors. Recent studies have shown that …

In this study we assessed whether gliomas could be subdivided into different molecular
subtypes by immunohistochemistry (IHC) reminiscent of those first described by Verhaak et …

Since the introduction of integrated histological and molecular diagnoses by the 2016 World
Health Organization (WHO) Classification of Tumors of the Nervous System, an increasing …

Abstract Background and Objective Determination of isocitrate dehydrogenase (IDH) 1/2
mutational status is crucial for a glioma diagnosis. It is common for IDH mutational status to …

Introduction Recent developments in genomic sequencing have led to the identification of
somatic mutations in isocitrate dehydrogenase 1 (IDH1) in various malignancies. IDH1 …

Glioblastoma Multiforme (GBM) is the most serious type of glioma with the highest
tumorigenesis rate. Studies have found that the increased expression levels of matrix …