Abstract Type 1 diabetes (T1D), a severe disease requiring intensive insulin treatment,
carries an increased risk for complications and reduced lifespan. Certain viruses have been …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression post-
transcriptionally and influence numerous biological processes. Aberrant miRNA expression …

Aims/hypothesis tRNAs play a central role in protein synthesis. Besides this canonical
function, they were recently found to generate non-coding RNA fragments (tRFs) regulating …

Human islets of Langerhans are composed mostly of glucagon-secreting α cells and insulin-
secreting β cells closely intermingled one another. Current methods for identifying α and β …

Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1
diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in …

Aims/hypothesis Surviving beta cells in type 1 diabetes respond to inflammation by
upregulating programmed death-ligand 1 (PD-L1) to engage immune cell programmed …

Preserving the function and survival of pancreatic beta-cells, in order to achieve long-term
glycemic control and prevent complications, is an essential feature for an innovative drug to …

Environmental factors, in particular viral infections, are thought to have an important role in
the pathogenesis of type 1 diabetes mellitus (T1DM). The COVID-19 pandemic reinforced …

To the Editor: I comment on the original publication 'Interferons are key cytokines acting on
pancreatic islets in type 1 diabetes' by Coomans de Brachène et al [1]. Based upon in vitro …