IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
J Bennett, DT Starczynowski - Current Opinion in Hematology, 2022 - journals.lww.com
IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …
Regulation of innate immune signaling by IRAK proteins
M Pereira, RT Gazzinelli - Frontiers in Immunology, 2023 - frontiersin.org
The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount
importance in coordinating the early immune response to pathogens. Signaling via most …
importance in coordinating the early immune response to pathogens. Signaling via most …
IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis
FG Thiel, S Asgarbeik, J Glaubitz, A Wilden… - Scientific Reports, 2023 - nature.com
Acute pancreatitis (AP), which is characterized by self-digestion of the pancreas by its own
prematurely activated digestive proteases, is a major reason for hospitalization. The …
prematurely activated digestive proteases, is a major reason for hospitalization. The …
Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology
Introduction Abnormal gene expression patterns may contribute to the onset and
progression of late‐onset Alzheimer's disease (LOAD). Methods We performed …
progression of late‐onset Alzheimer's disease (LOAD). Methods We performed …
Moonlighting proteins shine new light on molecular signaling niches
Plants as sessile organisms face daily environmental challenges and have developed
highly nuanced signaling systems to enable suitable growth, development, defense, or …
highly nuanced signaling systems to enable suitable growth, development, defense, or …
A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis
Background Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …
Modulation of inflammatory cytokine production in human monocytes by cGMP and IRAK3
Interleukin-1 receptor-associated kinase-3 (IRAK3) is a critical checkpoint molecule of
inflammatory responses in the innate immune system. The pseudokinase domain of IRAK3 …
inflammatory responses in the innate immune system. The pseudokinase domain of IRAK3 …
Identification of NLR-associated amyloid signaling motifs in bacterial genomes
In filamentous fungi, amyloid signaling sequences allow Nod-like receptors (NLRs) to
activate downstream cell-death inducing proteins with HeLo and HeLo-like (HELL) domains …
activate downstream cell-death inducing proteins with HeLo and HeLo-like (HELL) domains …
Mutations in the vicinity of the IRAK3 guanylate cyclase center impact its subcellular localization and ability to modulate inflammatory signaling in immortalized cell …
Interleukin-1 receptor-associated kinase 3 (IRAK3) modulates the magnitude of cellular
responses to ligands perceived by interleukin-1 receptors (IL-1Rs) and Toll-like receptors …
responses to ligands perceived by interleukin-1 receptors (IL-1Rs) and Toll-like receptors …
Integrated multi-omic analysis reveals immunosuppressive phenotype associated with poor outcomes in high-grade serous ovarian cancer
R Keathley, M Kocherginsky, R Davuluri, D Matei - Cancers, 2023 - mdpi.com
Simple Summary Tumor classification based on genomic features may be able to identify
new clinically relevant subtypes and disease characteristics. By integrating multiple levels of …
new clinically relevant subtypes and disease characteristics. By integrating multiple levels of …