Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Malaria, a nocuous disease, which has become a major challenge for the health resulting in
deaths of millions of people around the globe. Malaria is a parasitic disease propagated by …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

Abstract Imidazo [1, 2-b] pyridazine scaffold represents an important class of heterocyclic
nucleus which provides various bioactives molecules. Among them, the successful kinase …

Further structure–activity relationship (SAR) studies on the recently identified pyrido [1, 2-a]
benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically …

This review highlights the use of functionalized organo-Li,-Mg and-Zn reagents for the
construction and selective functionalization of 5-and 6-membered fused bicyclic …

Plasmodium falciparum phosphatidylinositol 4-kinase (Pf PI4K) has emerged as a promising
new drug target for novel antimalarial therapeutics. In the absence of a reliable high …

Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is
not ideal for several reasons including lack of potency against the juvenile stage of the …

The continuous culture of Plasmodium falciparum is often seen as a means to an end, that
end being to probe the biology of the parasite in question, and ultimately for many in the …

Disubstituted imidazo [1, 2-b] pyridazine derivatives were synthesized to identify new
inhibitors of various eukaryotic kinases, including mammalian and protozoan kinases …