[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles

NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Molecular physiology of TRPV channels: controversies and future challenges

T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Structure of the cold-and menthol-sensing ion channel TRPM8

Y Yin, M Wu, L Zubcevic, WF Borschel, GC Lander… - Science, 2018 - science.org
Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that
are involved in a variety of physiological processes. Within the TRPM family, member 8 …

Regulation of pain and itch by TRP channels

C Moore, R Gupta, SE Jordt, Y Chen, WB Liedtke - Neuroscience bulletin, 2018 - Springer
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

TRP channels and pain

D Julius - Annual review of cell and developmental biology, 2013 - annualreviews.org
Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Transient receptor potential channels in the vasculature

S Earley, JE Brayden - Physiological reviews, 2015 - journals.physiology.org
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Involvement of neural transient receptor potential channels in peripheral inflammation

HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

The transient receptor potential family of ion channels

B Nilius, G Owsianik - Genome biology, 2011 - Springer
The transient receptor potential (TRP) multigene superfamily encodes integral membrane
proteins that function as ion channels. Members of this family are conserved in yeast …

Peripheral thermosensation in mammals

J Vriens, B Nilius, T Voets - Nature Reviews Neuroscience, 2014 - nature.com
Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …