Various diseases and toxic factors easily impair cellular and organic functions in mammals.
Organ transplantation is used to rescue organ function, but is limited by scarce resources …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …

Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Mesenchymal stem cells (MSCs) have gained increasing attention as a potential approach
for the treatment of bone injuries due to their multi-lineage differentiation potential and also …

The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

In bone tissue engineering research, bioreactors designed for replicating the main features
of the complex native environment represent powerful investigation tools. Moreover, when …

Abstract Treatment of critical-size bone defects is a major medical challenge since neither
the bone tissue can regenerate nor current regenerative approaches are effective. Emerging …

Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based
on MSC secretion of paracrine factors. Several strategies have proposed to improve this are …

Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and
mental health of patients. Unfortunately, current surgical treatment techniques that are …

Human mesenchymal stem or stromal cells (hMSCs) are known for their potential in
regenerative medicine due to their differentiation abilities, secretion of trophic factors, and …