Toxicity of polyamines and their metabolic products
AE Pegg - Chemical research in toxicology, 2013 - ACS Publications
Polyamines are ubiquitous and essential components of mammalian cells. They have
multiple functions including critical roles in nucleic acid and protein synthesis, gene …
multiple functions including critical roles in nucleic acid and protein synthesis, gene …
Deception and Manipulation: The Arms of Leishmania, a Successful Parasite
P Cecílio, B Pérez-Cabezas, N Santarém… - Frontiers in …, 2014 - frontiersin.org
Leishmania spp. are intracellular parasitic protozoa responsible for a group of neglected
tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These …
tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These …
Recent advances in chemotherapeutics for leishmaniasis: Importance of the cellular biochemistry of the parasite and its molecular interaction with the host
Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani …
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …
Unveiling the role of serine o-acetyltransferase in drug resistance and oxidative stress tolerance in Leishmania donovani through the regulation of thiol-based redox …
Understanding the unique metabolic pathway of L. donovani is crucial for comprehending its
biology under oxidative stress conditions. The de novo cysteine biosynthetic pathway of L …
biology under oxidative stress conditions. The de novo cysteine biosynthetic pathway of L …
Current therapeutics, their problems and thiol metabolism as potential drug targets in leishmaniasis
Leishmaniasis is one of the six diseases regarded most neglected by World Health
Organization which is predominant in developing countries. Clinically, among the different …
Organization which is predominant in developing countries. Clinically, among the different …
Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an
ability to sense and adapt to changes in the microenvironment. However, little is known …
ability to sense and adapt to changes in the microenvironment. However, little is known …
Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window
Leishmania donovani, a protozoan parasite, is the causative agent of visceral leishmaniasis.
It lives and multiplies within the harsh environment of macrophages. In order to investigate …
It lives and multiplies within the harsh environment of macrophages. In order to investigate …
[HTML][HTML] Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania …
Leishmania donovani is the causative organism of the neglected human disease known as
visceral leishmaniasis which is often fatal, if left untreated. The cysteine biosynthesis …
visceral leishmaniasis which is often fatal, if left untreated. The cysteine biosynthesis …
Interaction between Cfd1 and Nbp35 proteins involved in cytosolic FeS cluster assembly machinery deciphers a stable complexation in Leishmania donovani
Leishmania donovani is the causative unicellular parasite for visceral leishmaniasis (VL);
and Fesingle bondS proteins are likely to be very essential for their survival and viability …
and Fesingle bondS proteins are likely to be very essential for their survival and viability …