Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

With the advent of nicotine replacement therapy, the consumption of the nicotine is on the
rise. Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has …

Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy
medicine and medicine be thy food.” Exploring the association between diet and health …

Garcinol is the main medicinal component of the dried fruit rind of Garcinia indica (G. indica),
which has traditionally been extensively used to treat gastric ailments and skin irritation. In …

Constitutive activation of proinflammatory transcription factors such as STAT3 and NF-κB
plays a pivotal role in the proliferation and survival of squamous cell carcinoma of the head …

Abstract β-Adrenoceptors are broadly distributed in various tissues of the body. Stress
hormones regulate a panel of important physiological functions and disease states including …

Background Constitutive activation of signal transducer and activator of transcription 3
(STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety …

Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …

Breast cancer (BC) is a devastating disease in female around the world causing significant
health care burden in both developed and developing countries. In many cases BC has …

Anticancer properties of Garcinia indica–derived garcinol are just beginning to be
elucidated. We have earlier reported its cancer cell–specific induction of apoptosis in breast …